It is possible to hit the parasites without the scope and they can still be alive after losing all the parasites or die before hitting any by doing enough damage. There are two to five smaller parasites located inside their bodies that can only been seen with the Infrared Scope destroying these will cause extra damage to them. The attacks Regeneradores use depend on which limbs they still have.
Very rarely, they can be seen running. When fired at, their limbs can be blown off, but after a short time they regenerate back. They usually approach the player by walking however, almost all encounters take place in small spaces and they have very fast and somewhat ranged attacks. They have a very large amount of health and drop 5,000 ₧ upon defeat. Before spotting the player, Regeneradores stand in place and take distinct heavy breaths, making it easy to tell if they are near. Regeneradores are only present in the main game and none of them are required to be defeated.